On the surface
- Fort Daxio: A redoubt of the Republic of Tal'Dorei situated in the western reaches of the mountain range, guarding the Othendin Pass.
- Gatshadow Mountain: A massive spire at the southeastern tip of the range warped by the power of Tharizdun, who was imprisoned beneath the mountain. At various times, served as a base for Tharizdun's priest Acek Orattim, the dying mage Drath Mephruhn who tried to take over Grog Strongjaw's body, and the ancient black dragon Umbrasyl during his domination of Westruun.
- Lyrengorn: A wood elf city in the far north of the range.
- The Palace of Wonder: Originally a citadel of early settlers from Issylra in the remote northwestern Cliffkeeps, now headquarters of the League of Miracles.
- The Pools of Wittebak: A former gnomish city abandoned after being ruined by hill giants.
- Reaching Bluff: A village in a fertile valley in the remote northwestern reaches of the Cliffkeeps that dug up a Luxon beacon and tried to keep it a closely guarded secret.
- Terrah: The home village of the Earth Ashari, located in a valley in the center of the range.
Below the ground
- The Emberhold: Fortress capital of a kingdom of duergar.
- Kraghammer: Major dwarven city-state.
- Vulkanon: City of fire giants.
- Yug'Voril: A mind flayer colony once controlled by K'Varn.
Inhabitants
The most prominent inhabitants of the Cliffkeeps are humanoid: dwarves, half-giants, goblins, and kobolds. The range is also home to a wide variety of giants: cyclops, fire giants, frost giants, hill giants, ettins, and trolls. Less prominently, there are catfolk living in the caves of the Cliffkeeps. Deep beneath the ground, the Cliffkeep Mountains house the myconid race. The lower temperatures of the peaks favor the presence of cold snap spirits.
Society and economy
In 812 PD, the majority of people who lived in this region worshiped Moradin, the All-Hammer, Kord, the Stormlord, and Pelor, the Dawnfather while the minority worshiped Bahamut, the Platinum Dragon. By 836 PD, Sehanine, the Moonweaver, Asmodeus, the Lord of the Hells, and Tiamat, the Scaled Tyrant gained minority followings.
In 812 PD, the settlements of the region imported lumber, spices, fish, grain, and livestock, and exported precious gems, industrial metals, gold, silver, platinum, mithral, cobalt, fine stonework, jewelry, fungal produce, weapons, and armor. By 836 PD, the settlements started to export quartz and granite as well.